The official journal of The Sri Lanka Veterinary Association
THE DIAGNOSIS AND TREATMENT OF ACQUIRED MYASTHENIA GRAVIS IN TWO ADULT DOGS USING ORAL NEOSTIGMINE BROMIDE
Journal - Sri Lanka Veterinary Journal (volume: 63 (1))
Volume - 63 (1)
Year - 2016
Page Number - 27
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Clinical Communication

S.L.Vet.J. 2016, 63(1) (A): 27-31

Clinical communication


THE DIAGNOSIS AND TREATMENT OF ACQUIRED MYASTHENIA GRAVIS IN TWO ADULT DOGS USING ORAL NEOSTIGMINE BROMIDE

D.R.A. Dissanayake, I. D. Silva, Y.U. de Silva Senapathi, D.D.N. de Silva, M.D.H.S.
Mallikarachchi, W.G.D.A. Gunathilaka, W.R.B Kumara,
E. Rajapaksha and W.C. R. Fernando

Veterinary Teaching Hospital, Department of Veterinary Clinical Science, Faculty of Veterinary Medicine and
Animal Science, University of Peradeniya

Summary: Two adult dogs aged 3.5 and 9 years were diagnosed with acquired Myasthenia Gravis (MG) based on clinical signs and positive response to oral neostigmine bromide (0.25mg/Kg BW) within 4 hours of oral administration. Both patients were successfully treated using neostigmine (1mg/Kg BW daily) alone or with neostigmine (1mg/Kg BW daily) and prednisolone (1mg/Kg BW, q12h) combination. Serum alkaline phosphatase and albumin/ globulin ratio monitored in one of the above patients starting from one month prior to development of generalized clinical signs until complete recovery, showed significant alterations which can be used in diagnosing MG and in monitoring the response to treatment.

Corresponding author: drad199@gmail.com

How to cite:

D.R.A. Dissanayake, I. D. Silva, Y.U. de Silva Senapathi, D.D.N. de Silva, M.D.H.S. Mallikarachchi, W.G.D.A. Gunathilaka, W.R.B Kumara, E. Rajapaksha and W.C. R. Fernando, (2016). The diagnosis and treatment of acquired myasthenia gravis in two adult dogs using oral neostigmine bromide. Sri Lanka Veterinary Journal. 63(1) (A), pp 27-31.

Keywords: Myasthenia Gravis, Dog, Neostigmine bromide,Serum alkaline phosphatase, Albumin/ globulin ratio